Modacharge 200
Price range: $120.00 through $255.00
Modacharge 200 mg is formulated to support wakefulness and mental clarity, helping you stay alert, focused, and productive during long or demanding days with smooth, sustained energy.
DESCRIPTION
Modacharge 200 mg is a medicinal drug containing modafinil which is alertness enhancing medication indicated for the treatment of excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift work sleep disorder. It works by increasing extracellular dopamine level in the brain, also boost alertness and arousal.
How does Modacharge 200 mg work?
- Dopamine is neurotransmitter that leads to motivation, reward attention, and wakefulness that may inhibits dopamine reuptake by increasing level of dopamine.
- It may also inhibit norepinephrine reuptake that helps in boosting alertness and arousal.
- By just slightly increasing histamine release may supports alertness and wakefulness by hypothalamus.
- GABA and glutamate modulation may help in shifting balance toward excitation, and hence promote alertness and focus.
ADDITIONAL INFORMATION
Key Features
| About (Modacharge 200 mg) |
| Drug Class: Central Nervous System Stimulant |
| Subclass: Eukratonic Agent |
| Product Details | |
| Composition | Active ingredients:
Inactive ingredients:
|
| Packaging Type | Blister |
| Pack Size | 10*10 |
| Dosage | 200 mg |
| Therapeutic class | Treatment of Narcolepsy, Sleep Disorder and OSA related sleepiness |
| Action Class | Dopamine Reuptake inhibitor |
| Chemical class | Benzhydryl Sulfinyl acetamide derivative |
| Manufacturer | Mednova |
| Shelf Life | 24 months after the date of manufacturing |
| Usages | Improves Wakefulness in patients with excessive daytime sleepiness |
| Country of Origin | India |
| Storage | Store at room temperature, 20°C to 25°C, away from moisture and sunlight. |
USAGE
- Modacharge 200 mg is used in Narcolepsy and Obstructive Sleep Apnea conditions.
- It can be also used during long shifts and Shift-Work Disorder condition.
DOSAGE
- The starting dose of Modacharge can be 200 mg and is taken orally daily in the morning.
- Once a day is highly recommended.
- According to Tolerability and requirement of individual it may be increased.
SIDE EFFECTS
- Anxiety
- Dizziness
- Headache
- Dry Mouth
- Insomnia
- Headache
- Nasal congestion
- Pharyngitis
- Palpitations
- Increased Blood Pressure
Interactions
- CYP3A4 Inducers like rifampin, phenytoin, carbamazepine may lead to decrease modafinil plasma level and may reduce its efficacy.
- CYP3A4 Inhibitors like ketoconazole, itraconazole, and ritonavir may increase modafinil plasma levels and increase the risk of toxicity.
- CYP2C19 Substrates like diazepam, omeprazole, clopidogrel may interacts with modafinil adversely.
- It may show interaction with caffeine and alcohol.
Pharmacokinetics
- Rapid oral absorption; bioavailability ~40% due to first-pass hepatic metabolism. Peak plasma concentration reached in 2–4 h post-dose. Food delays absorption slightly but does not affect total exposure.
- Volume of distribution approx. 0.9 L/kg. Plasma protein binding approx. 60% (primarily to albumin). It crosses the blood-brain barrier effectively in order to exert CNS effects.
- Extensively metabolized in liver primarily via, CYP3A4/5 (major route), a small contribution from CYP1A2 and CYP2C19
- Major inactive metabolites: Modafinil acid and modafinil sulfone.
- Excretion Primarily renal (~80% as metabolites); minor fecal excretion (~1%). Elimination half-life: approximately 15 hours (range: 10–18 h). Steady-state plasma levels achieved after 2–4 days of continuous dosing.
Precautions
- Risk of serious cutaneous adverse reactions (including Stevens-Johnson Syndrome) stop immediately if rash occurs.
- Psychiatric symptoms: anxiety, hallucinations, mania-caution in bipolar patients.
- Cardiovascular: Use with caution in patients with hypertension, recent myocardial infarction, or unstable angina.
CONCLUSION
The potent wakefulness-promoting Modacharge 200 mg (modafinil) is known for its well-understood pharmacokinetic profile, allowing for once a day dosing.
which is an effective alertness enhancing medication indicated for the treatment of excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift work sleep disorder. Patients must be carefully managed to limit the potential adverse effects of such drugs and may consult a healthcare provider or doctor prior taking such medications.
FAQS
What for Modacharge 200 mg used for?
Modacharge 200 mg can be used in treating conditions like Narcolepsy, Shift-Work Disorder and Sleep Apnea.
How does Modacharge 200 mg work?
Modacharge 200 mg works by increasing extracellular dopamine level in the brain, also boost alertness and arousal.
Is Modacharge 200 mg safe for everyone?
Yes, Modacharge 200 mg is generally safe but avoid caffeine and alcohol while taking medicine and consult a doctor prior.
Is Modacharge 200 mg can be taken at night?
No, it is best in the morning and in the night, it may can lead to insomnia.
Who should avoid Modacharge 200 mg?
The one with prior medical conditions like cardiovascular, pregnancy or breast feeding may avoid taking Modacharge 200 mg.
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